Title : Association between MAFLD and vitamin D in obesity
Abstract:
Metabolic Associated Fatty Liver Disease (MALFLD) is the new term to Nonalcoholic fatty liver disease (NAFLD), that has become one of the most common chronic liver diseases worldwide. MAFLD is characterized by an accumulation of fat in the liver in the absence of such secondary causes as alcohol abuse, viral hepatitis, and so forth, while presenting such wide-ranging histological features as simple macrovesicular steatosis and nonalcoholic steatohepatitis (NASH) that can evolve into fibrosis, cirrhosis, or hepatocellular carcinoma.
Vitamin D deficiency (VDD) can result from problems relating to the absorption of vitamin D (25(OH)D), hydroxylation due to liver failure, inadequate exposure to sunlight and other factors. It is one of the most prevalent micronutrient deficiencies in the world, with a billion people estimated to be deficient. Individuals with obesity, including those suffering from liver disease, are more susceptible to VDD. A potential explanation for this deficiency is, when there is damage of the liver, synthesis of 25(OH)D may be impaired by the presence of steatosis. VDD can exacerbate MAFLD at least in part through an inflammatory-mediated pathway, given how vitamin D mediates its intracellular signals via the vitamin D receptor (VDR), which is constitutively expressed in the liver.
There is limited information on the potential role VDD plays in MAFLD diagnosed via liver biopsy, mainly where NASH is concerned.
Thus, the aim of this presentation will be demonstrating the relationship between serum 25(OH)D concentrations and MAFLD staging, mainly, as diagnosed by liver biopsy, the gold standard method, in class III obesity [Body Mass Index (BMI) ≥ 40kg/m2].
Audience Take Away Notes:
- Recent researches about relationship between Metabolic Associated Fatty Liver Disease and Deficiency of Vitamin D
- Impact of steatosis hepatic in conversion of 25(OH)D
- The results will present could instigate researches to find out more information about this relationship, mainly provide answers to use in a clinical practice.
