Title : A study on the comparison of the efficacy of major compounds found in natural medicinal plants effective for SARS-CoV-2 with reference drugs
Abstract:
The drug studies related to SARS-CoV-2 have recently been a major epidemic and humanity's efforts to find a cure have gained a great momentum. Experimental and clinical studies, studies showing that Molnupiravir is effective on this virus show that this compound can be used as a reference drug. The aim of this study is to identify natural compounds that are more effective on SARS-CoV-2 than the reference drug Molnupiravir. The interaction of the reference drug and natural active molecules with the SARS-CoV-2 receptors was determined by chemical calculation methods, and the effect points on the receptors and the effects of the main active substances in medicinal plants on the receptors on this virus were determined in the same way. What kind of intermolecular bonds are formed in this interaction and from which points they interact are investigated with this method. This study is very important in terms of giving direction to experimental studies and preventing time and material loss. By comparing the main active natural substances in selected medicinal plants with Molnupiravir, it was tried to determine how the effect on the interaction and inhibition of SARS-CoV-2 with its receptors was.
Audience Take Away:
- Listeners can discover compounds with similar properties to the active ingredients here
- This study guides experimental and clinical studies
- This research will assist in areas related to drug discovery in this field
- This provides a practical solution that a drug explorer can simplify or make more efficient.
- This study will provide new information that will improve the accuracy of drug discovery and assist in new drug design.
