Title : Neptune krill oil and fish oil possess anti-pain and anti-inflammation like effects of against carrageenan induced inflammation in mice
Abstract:
Although inflammation is a reactive to injurious stimuli and considered as beneficial process in body, but it causes some discomforts, such as pain. Murine dietary contains appreciable amounts of fatty acids and antioxidants which encourages researchers to focus on their potential therapeutic effects. This study is aimed to examine the analgesic and anti-inflammatory activity of Neptune krill oil (NKO) and fish oil (FO) in rodent model which are two well-known sources of rich content of n-3 polyunsaturated fatty acids (n-3 PUFAs), mostly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). NKO and FO were used at the same dose of 500 mg and also balanced at similar doses of EPA: 12 in NKO vs. 12 in FO wt%, DHA: 7 NKO vs. 8 FO wt%. Application of NKO and FO in acetic acid-induced writhing effect, hot plate, and formalin induced test, indicated the nociceptive activity of the two tested drugs in comparison with normal saline. Also, the anti-inflammatory effect of these supplements was confirmed by carrageenan test. Analysis of cytokines levels in the blood samples of the mice after induction inflammation by carrageenan indicated decreased levels of those proteins compared to that in the normal groups. Both tested drugs, effectively could reduce severe inflammation and pain in rodents in comparison with the references drugs (depends on the tests); however, NKO was found to be more effective.
Audience Take Away Notes:
Although inflammation is a reactive to injurious stimuli and considered as beneficial process in body, but it causes some discomforts, such as pain. Nutrition plays a significant role in inhibition of pain and inflammation, for instance, murine dietary contains appreciable amounts of fatty acids and antioxidants which encourages researchers to focus on their potential therapeutic effects. This study is aimed to examine the analgesic and anti-inflammatory activity of Neptune krill oil (NKO) and fish oil (FO) in rodent model which are two well-known sources of rich content of n-3 polyunsaturated fatty acids (n-3 PUFAs), mostly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) types of breast cancer in vitro.
Both Krill and fish oil supplements, showed anti-pain and anti-inflammation effects in mice model.
The exact mechanism underlying this activity is not clear yet. Moreover, the bioactive compounds of each supplements need to be more studied in terms of such bio activity.
- Faculty of Medicine: Clinical trial design
- Faculty of chemistry: Identification of bioactive compounds of the two oily supplements. Designing and developing molecules with a scaffold structurally similar to that of the bioactive compounds.
- Faculty of nutrition/ Health and Medical Science: Studying the bior activity of new emerged drugs
