Title : Low protein Genmai (Brown rice) for the prevention of CKD progression by improving the gut-kidney axis
Abstract:
In response to the enormous increase in medical costs in many, encouragement of healthy longevity by changes in dietary habits is mandatory. An excellent example of the necessity of dietary therapy is chronic kidney disease (CKD). Chronic kidney disease is one of the targets because of its non-curability and increases worldwide. Proteinuria is a good marker for clinical progression, so solution-oriented Pro- & Post study make it easy for clinicians and dieticians to get evidence of dietary therapy
We have performed eight intervention studies (five in Japan, two in China, and one in Indonesia) using the newly developed processed low-protein genmai (Gogyo-Genmai: JAS0027) and showed that decreasing uremic toxins through the improvement of uremic dysbiosis and leaky gut prevented the progression of chronic kidney disease (CKD). It was effective in any stage from CKD3 to CKD5 by only substituting white rice to the low protein genmai package without strict limitations for side dishes.
Gogyo-genmai is characterized by (1) energy similar to white rice, (2) protein content of less than one-tenth, (3) almost zero potassium, and (4) phosphorus of less than one-quarter, (5) dietary fiber, (6) ?-oryzanol, and (7) antioxidant capacity. It could open a new era of dietary therapy for CKD with a plant-based PLADO diet.
