Title : The synergistic effect of compound dietary fiber and Parabacteroides distasonis on alleviating placental aging and improving GDM
Abstract:
The effects of dietary fiber vary depending on its type and the composition of an individual’s gut microbiota. Certain microbes act as probiotics only when appropriate dietary fiber is present, and dietary fiber is also combined with specific microbes to maximize its efficacy. In our previous randomized controlled trial (RCT) investigating the intervention of compound dietary fiber (CDF) in gestational diabetes mellitus (GDM), we found that pregnant women with a low baseline abundance of intestinal P. distasonis exhibited poor efficacy, suggesting that CDF may depend on this microbe to function as an anti-GDM agent. Animal experiments also demonstrated that the synergistic effect of CDF and P. distasonis on improving GDM was significantly stronger than that of a single intervention. Mechanistically, Retinoic acid (RA) produced from the fermentation of CDF by P. distasonis inhibits pyroptosis in placental macrophages, alleviating senescence in trophoblast cells and thereby improving GDM. Our study offers new theoretical insights into probiotic-prebiotic interactions and their application for precise treatment of GDM through gut-flora-placenta axis.
Keywords: Dietary Fiber; Gestational Diabetes Mellitus; Gut Microbiota; P. distasonis; Ricinoleic acid
