Title : Association between lipid accumulation product and stress urinary incontinence in US females: Mediation role of oxidative stress
Abstract:
Purpose:
The relationship between lipid accumulation product (LAP) and stress urinary incontinence (SUI) in females remains unclear, and the potential mediating role of oxidative stress and inflammatory factors in this process has not been extensively studied. This analysis aims to explore the relationship between elevated LAP indices and SUI in women, with a particular focus on examining the mediating roles of oxidative stress and inflammatory factors in this association.
Methods:
Data from 4,292 participants across six consecutive cycles of the National Health and Nutrition Examination Survey (NHANES) were subjected to analysis. To investigate the association between LAP and the prevalence of SUI in adult women, various covariates were adjusted, logistic regression analysis and subgroup analysis were utilized. Additionally, mediation analysis was employed to evaluate the potential contributions of oxidative stress and inflammatory factors to this association.
Results:
The prevalence of SUI among US females was 46.02%. Following adjustment for confounding factors, the odds ratio (OR) for LAP and SUI was 1.003 (95% CI = 1.001-1.004, p = 0.002), indicating a positive correlation. Gamma-glutamyl transferase (GGT) mediated this relationship, explaining 40.0% of the effect (p = 0.036).
Conclusions:
The findings in this study indicate that LAP is positively associated with the prevalence of SUI in women, with oxidative stress potentially serving as a mediator in this relationship.
Keywords: Nutrition Surveys; lipid accumulation product; stress urinary incontinence; mediation analysis; oxidative stress.
