Title : Biochemical and lipid profile alterations in wistar rats following toluene exposure
Abstract:
The volatile organic compound toluene is known for its toxicity to humans. This study aimed to evaluate its effects on lipid profile and certain biochemical markers in Wistar rats. Forty adult-female Wistar rats were distributed across ten groups (four rats each). Group 1 received distilled water, while groups 2 to 9 were administered increasing doses of analytical grade toluene over a 28-day period. Unfortunately, animals in groups 6 to 10 succumbed during the study, while those in groups 1 to 5 were euthanized after 28 days under chloroform anesthesia for blood sample collection via cardiac puncture. The results indicated a significant elevation (p<0.05) in serum levels of triglycerides, total bilirubin, low-density lipoprotein and total cholesterol following toluene exposure. Conversely, concentrations of high-density lipoprotein, albumin and total protein were significantly reduced (p<0.05). These findings suggest that toluene adversely affects lipid profile, total protein, albumin, and total bilirubin, potentially through its systemic influence on oxidative stress, inflammation, and liver function.
Keywords: High-Density Lipoprotein, Toluene, Total Bilirubin, Total Protein, Bilirubin, Triglycerides, Total Cholesterol, Low-Density Lipoprotein.
