Title : Regulation of aquatic characteristic matrix on metabolism of uric acid
Abstract:
Abnormal uric acid (UA) metabolism leads to the increase of serum UA level and causes hyperuricemia (HUA), which seriously threatens human well-being. Presently, dietary adjustments have become a crucial strategy in managing serum UA levels among individuals grappling with hyperuricemia and gout. Given its unique ecosystem, the ocean hosts a plethora of organisms boasting distinct structures and active components. The marine bioactive substances, such as bioactive peptides, polysaccharides, lipids and small molecules, have garnered attention in the research and development of modern functional foods and biomedicine due to their profound efficacy and distinctive compositions. Notably, the functional components of marine foods have been studied for their potential in regulating UA metabolism. Current studies have shown that the processes through which marine compounds demonstrate their anti-HUA effects likely involve several mechanisms:
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Inhibition of purine metabolic enzyme activity, leading to a decrease in UA production.
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Regulation of renal UA transporter expression, which helps maintain intestinal balance, facilitating UA excretion while impeding reabsorption.
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Restoration of gut microbial, addressing inflammatory reactions and oxidative harm induced by UA. This aids in safeguarding the body's normal functioning.
Given the diverse and highly abundant bioactive compounds found in seafood that may help regulate UA metabolism and prevent hyperuricemia, it is essential to reconsider the idea that all seafood, particularly those with low purine content, should be strictly avoided by individuals with HUA. This perspective highlights the importance of exploring the potential therapeutic benefits of marine foods in managing HUA condition. By identifying and understanding these bioactive compounds, we can better tailor dietary recommendations and promote the consumption of marine foods as part of a balanced and healthy diet for general population and individuals with HUA conditions.
