Metabolomics and systems biology in nutrition provide a comprehensive understanding of how dietary components influence metabolic pathways and overall health. Metabolomics, the large-scale study of metabolites, reveals intricate interactions between nutrients and cellular processes, offering insights into personalized nutrition strategies. Systems biology integrates data from various biological systems to map the complex networks that govern metabolic regulation and disease prevention. By analyzing the effects of different diets and nutrients, researchers can identify biomarkers for conditions such as obesity, diabetes, and cardiovascular diseases. Metabolomics and Systems Biology in Nutrition enable precision approaches to diet planning, promoting targeted interventions to optimize metabolic health and reduce disease risk.